Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection.

ABSTRACT: A craniotomy is a neurosurgical procedure performed to access the intracranial space. In 3-5% of cases, infections can develop, most caused by Staphylococcus aureus biofilm formation on the skull surface. Medical management of this infection is difficult, as biofilm properties confer immune and antimicrobial recalcitrance to the infection and necessitate additional surgical procedures. Furthermore, treatment failure rates can be appreciably high. These factors, compounded with rapidly expanding rates of antimicrobial resistance, highlight the need to develop alternative treatment strategies to target and reverse the immune dysfunction that occurs during biofilm infection. Our recent work has identified CD4⁺ Th1 and Th17 cells as potent regulators of innate immune cell activation

SUBMITTER: Van Roy Z 

PROVIDER: S-EPMC11847343 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature