Cancer-secreted exosomal miR-1825 induces angiogenesis to promote colorectal cancer metastasis.

ABSTRACT:

Background

Angiogenesis is one of the important factors related to tumorigenesis, invasion, and metastasis. Cancer-secreted exosomes are essential mediators of intercellular cross-talk and participate in angiogenesis and metastasis. Unveiling the mechanism of angiogenesis is an important way to develop anti-angiogenesis therapeutic strategies to against cancer progression.

Methods

miR-1825 expression and relationship with microvascular density were validated in colorectal cancer (CRC) by in situ hybridization (ISH) staining and immunohistochemistry (IHC). Sequential differential centrifugation, transmission electron microscopy, and western blotting analysis were used to extract and characterize exosomes. The effort of exosomal miR-1825 on endothelial cells was examined by tr

SUBMITTER: Sun J 

PROVIDER: S-EPMC11847347 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature