Excess mortality in COVID-19-negative people with non-communicable disorders during the first pandemic wave.

ABSTRACT:

Background

Estimating the indirect mortality due to COVID-19 is of the utmost importance to develop adequate public health policy during future outbreaks.

Methods

From province-wide administrative datasets, we identified British Columbians who tested negative for COVID-19 during the first wave and never tested positive throughout 2020. We obtained a pre-pandemic (2018) cohort matched on age, sex, history of non-communicable disorders (NCDs), multimorbidity, and severity/acuity, and implemented a doubly robust estimation of the effect of the first pandemic wave on mortality.

Results

The adjusted odds ratio (AOR) of death was 3.2 times higher for a 2020 cohort who tested negative for COVID-19 (n = 123,133), compared to matched pre-pandemic controls. In both cohorts, a m

SUBMITTER: Vigo DV 

PROVIDER: S-EPMC11847353 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature