Compound kushen injection improves radiation enteritis via cannabinoid receptor 1 in rats.

ABSTRACT:

Background

Clinical studies have shown that Compound Kushen Injection (CKI) can alleviate the inflammatory symptoms of radiation enteritis. However, the mechanism of action remains unclear. The aim of this study was to explore the possible targets and mechanisms of CKI in the treatment of radiation enteritis.

Methods

Network pharmacology was used to predict the potential targets of CKI for the treatment of radiation enteritis, and GO and KEGG enrichment analyses were subsequently performed. SD rats were randomly divided into one of the following groups: control, model, CB1 agonist, CKI and CKI + CB1 antagonist. Except for the control group, the remaining groups were irradiated the abdomen with 6 MV medical high-energy x-ray linear accelerator to establish the model of radiat

SUBMITTER: Xu W 

PROVIDER: S-EPMC11847357 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature