Development of animal model for anterior open bite and mechanism of temporomandibular joint morphological change: an implication for MAC surgery.

ABSTRACT:

Background

Although mandibular autorotation concept (MAC) surgery is a novel technique for addressing long-term stability issues in patients with mandibular retrusion and open bite accompanied by temporomandibular joint osteoarthritis (TMJOA), studies on MAC surgery in animal models and its mechanisms are scarce. This study aimed to develop an animal model for anterior open bite and investigate the underlying histological and molecular mechanisms of TMJ changes, with the expectation of contributing to the MAC surgery concept.

Materials and methods

Thirty-six, 5-weeks-old female Wistar rats were randomly divided into three groups: (1) Bite-raise group (2-mm resin added to the upper molars at 5 weeks of age) (2), Recovery group (resin added at 5 weeks of age and removed at 13

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11847398 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature