Copper-catalyzed sulfonylation of alkenes with CH₃SSO₃Na.

ABSTRACT: A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CH₃SSO₃Na in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl methyl sulfones by forming C-S bonds. Using the C-H bond oxidation sulfonylation strategy with alkenes and Bunte salts, we successfully synthesized a total of twenty two compounds, including four examples of deuterium-substituted molecules, and demonstrated one example of a scale-up reaction.

SUBMITTER: Chen X 

PROVIDER: S-EPMC11847399 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature