Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.

Objective

To investigate associations between PFAS concentrations and miRNA levels in children.

Methods

Data from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from t

SUBMITTER: Li Y 

PROVIDER: S-EPMC11847561 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature