Differential gait features across Parkinson's disease clinical subtypes.

ABSTRACT:

Background

Clinical subtypes in Parkinson's disease including non-motor manifestations may be more beneficial than subtypes based upon motor manifestations alone. Inclusion of gait metrics may help identity targets for rehabilitation and potentially predict development of non-motor symptoms for individuals with Parkinson's disease. This study aims to characterize gait differences across established multi-domain subtypes.

Methods

"Motor Only", "Psychiatric & Motor" and "Cognitive & Motor" clinical subtypes were established through motor, cognitive, and psychiatric assessment. Walking was assessed in the "OFF" medication state. Multivariate analysis of variance identified differences in gait domains across clinical subtypes.

Findings

The "Motor Only" subtype exhibited t

SUBMITTER: Baudendistel ST 

PROVIDER: S-EPMC11847565 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature