Examining multimorbidity contributors to dementia over time.

ABSTRACT:

Introduction

Multimorbidity is associated with increased risk of dementia, but previous estimation of the joint contribution of constituent conditions to dementia incidence did not model additive contributions or temporal proximity in the sequential onset of conditions.

Methods

Data were analyzed from 9944 Health and Retirement Study participants and Medicare fee-for-service beneficiaries, ages 68-99, without Alzheimer's disease and related dementias (ADRD) at baseline, from 1998-2016. ADRD and chronic condition were encoded using validated claims algorithms. We estimated the absolute contribution of eight conditions to ADRD with the longitudinal extension of the average attributable fraction (LE-AAF).

Results

Hypertension, acute myocardial infarction, atrial fibrilla

SUBMITTER: Klee M 

PROVIDER: S-EPMC11847647 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature