Risk of adverse cardiovascular events following spinal cord injury in patients with osteoporosis: Real-world evidence.

ABSTRACT:

Introduction

Spinal cord injury (SCI) is associated with increased cardiovascular risks, and cardiovascular disease (CVD) remains a leading cause of death for individuals with SCI. Osteoporosis, a condition associated with SCI, has been linked to CVD. However, the cardiovascular risk profile of individuals with SCI with osteoporosis remains unclear.

Methods

We conducted a retrospective cohort study by using data from the TriNetX Research Network. We included adults with osteoporosis with or without a diagnosis of SCI between 2015 and 2020: case (SCI group, N = 7,308) and control (non-SCI group, N = 843,235) cohorts. Propensity score matching was performed to balance baseline characteristics between the cohorts (N = 7,296 in each group). A Cox regression

SUBMITTER: Kao SK 

PROVIDER: S-EPMC11847749 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature