Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model.

ABSTRACT:

Background

Although prosthetic conduits for coronary artery bypass grafting (CABG) are increasingly needed because of the limited availability and patency of autologous conduits, no alternatives have succeeded.

Methods

Sixteen sheep underwent CABG. Thirteen received a bioabsorbable polymer graft with an incorporated nitinol microskeleton (Xeltis coronary artery bypass graft [XABG]), and three received autologous saphenous vein grafts (SVG). Pathological evaluation was conducted at 12 months.

Results

In the XABG group, two sheep died perioperatively; two were sacrificed at 3 months (1 occluded, 1 patent) and two at 6 months (both patent). Two more died from occlusion at 9-10 months, and five survived with patent grafts at 12 months. All SVGs remained patent for 12 mont

SUBMITTER: Sato Y 

PROVIDER: S-EPMC11847836 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature