Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors.

ABSTRACT:

Objectives

Immune Checkpoint Inhibitors (ICI) are nowadays a cornerstone of anti-cancer treatments. However, the wide spectrum of immune-related adverse events (irAEs) represents a challenge in the oncological practice. Our objective is to document rare complications of ICI to help the community of onco-immunologists.

Methods

We reported the case of a severe myositis mimicking bulbar palsy treated in our Medical Oncology Department together with Internal Medicine Department. We present the clinical work-up (neurological exam, capillaroscopy) and the diagnostic tests (myositis specific and associated antibodies, nerve conduction study, electromyography) leading to this diagnosis. We also discussed the elimination of differential diagnoses (notably with normal MRI and cerebros

SUBMITTER: Rochigneux P 

PROVIDER: S-EPMC11847840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature