ADAM-multi: software to simulate complex breeding programs for animals and plants with different ploidy levels and generalized genotypic effect models to account for multiple alleles.

ABSTRACT: Stochastic simulation software, ADAM, has been developed for the purpose of breeding optimization in animals and plants, and for validation of statistical models used in genetic evaluations. Just like other common simulation programs, ADAM assumed the bi-allelic state of quantitative trait locus (QTL). While the bi-allelic state of marker loci is due to the common choice of genotyping technology of single nucleotide polymorphism (SNP) chip, the assumption may not hold for the linked QTL. In the version of ADAM-Multi, we employ a novel simulation model capable of simulating additive, dominance, and epistatic genotypic effects for species with different levels of ploidy, providing with a more realistic assumption of multiple allelism for QTL variants. When assuming bi-allelic QTL, our propos

SUBMITTER: Chu TT 

PROVIDER: S-EPMC11847855 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature