Patterns of sick leave and unemployment prior to a diagnosis of young onset Alzheimer's disease.

ABSTRACT:

Introduction

Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map adverse occupational events preceding YOAD diagnosis as potential prodromal signs.

Methods

In a register-based, incidence density matched nested case-control study, we examined unemployment and long-term sick leave among individuals diagnosed with YOAD in Danish memory clinics between 2016 and 2022 compared to controls over a 13-year period. Conditional logistic regression produced incidence rate ratios (IRRs).

Results

The study included 2434 cases and 12,170 controls. YOAD patients had higher rates of adverse occupational events, particularly long-term sick leave, starting from 8 years before diagnosis (IRR 1

SUBMITTER: Damsgaard L 

PROVIDER: S-EPMC11847975 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature