Characterizing the olfaction and dementia association in the community-based ARIC study.

ABSTRACT:

Introduction

Few studies have characterized the association of olfaction with dementia in detail across diverse sociodemographic subgroups.

Methods

We examined the association of one-time-point olfactory status with incident dementia overall and by age, race, sex, and apolipoprotein E (APOE) ε4 status (n = 4470, mean age: 75 ± 5 years, 21% Black), and 5-year olfactory change with incident dementia (n = 2658) in the community-based Atherosclerosis Risk in Communities (ARIC) study.

Results

Compared to good olfaction, moderate olfaction (hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 1.26 to 1.86), hyposmia (HR: 2.24, 95% CI: 1.81 to 2.78), and anosmia (HR: 3.47, 95% CI: 2.77 to 4.34) were all associated with higher dementia hazard; these associations were consis

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC11847982 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature