Moderation of midlife cognitive activity on tau-related cognitive impairment.

ABSTRACT:

Introduction

We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline.

Methods

Eighty-nine non-demented older adults from a Korean cohort underwent comprehensive evaluations, including CA assessments and tau neuroimaging at baseline, and Mini-Mental State Examination (MMSE) at baseline and the 2-year follow-up.

Results

Greater midlife CA was associated with higher MMSE scores in a given amount of tau pathology, whereas higher levels of midlife CA were associated with faster tau-related decline in MMSE scores, particularly in individuals with mild cognitive impairment. Late-life CA did not exhibit any interaction with tau on either MMSE scores or their 2-ye

SUBMITTER: Ko K 

PROVIDER: S-EPMC11847999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature