Longitudinal patterns of brain aging and neurodegeneration among older adults with dual decline in memory and gait.

ABSTRACT:

Introduction

Dual cognitive and mobility decline is more strongly associated with dementia risk than cognitive decline only. It remains unknown whether this syndrome is associated with brain atrophy patterns, white matter (WM) damage, or pathology.

Methods

In the Baltimore Longitudinal Study of Aging participants with and without dual decline, we used linear mixed-effects models to compare up to 13-year longitudinal changes in MRI-derived atrophy patterns, WM hyperintensities (n = 339), microstructure (n = 307), plasma glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), amyloid beta 42/40 (Aβ_42/40) ratio (n = 349), and phosphorylated tau 181 (pTau181) (n = 258).

Results

Those experiencing dual decline showed accelerated atrophy in media

SUBMITTER: Tian Q 

PROVIDER: S-EPMC11848002 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature