Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An EHR Based Study From Colombia.

ABSTRACT:

Objectives

Most bipolar disorder (BD) patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study aims to identify features predictive of the conversion from Major Depressive Disorder (MDD) to BD by leveraging electronic health record (EHR) data from the Clínica San Juan de Dios Manizales in Colombia.

Methods

We employed a multivariable Cox regression model to identify important predictors of conversion from MDD to BD.

Results

Analyzing 15 years of EHR data from 13,607 patients diagnosed with MDD, a total of 1610 (11.8%) transitioned to BD. Predictive features of the conversion to BD included severity of the initial MDD episode, presence of psychosis and hospitalization at first episode, family his

SUBMITTER: Service SK 

PROVIDER: S-EPMC11848012 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature