Physical activity may protect myelin via modulation of high-density lipoprotein.

ABSTRACT:

Introduction

Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied.

Methods

We assessed cross-sectionally whether serum high-density lipoprotein (HDL), low-density lipoprotein, and triglycerides moderated the association between physical activity and in vivo myelin in older individuals with CSVD and mild cognitive impairment.

Results

We included 81 highly educated, community-dwelling older individuals (mean age 74.57 years), 64% of whom were female. Regression models revealed that HDL levels significantly moderated the relationship between physical activity and myelin in the sagittal s

SUBMITTER: Boa Sorte Silva NC 

PROVIDER: S-EPMC11848041 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature