Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET.

ABSTRACT:

Introduction

Limited data exist on the utility of plasma biomarkers to predict incident abnormal amyloid positron emission tomography (PET). In this study we evaluate the association of plasma Alzheimer's disease (AD) biomarkers with amyloid PET progression among initially amyloid PET negative (A-) individuals.

Methods

We included 290 A-, cognitively unimpaired Mayo Clinic Study of Aging participants. We estimated the association of each baseline plasma biomarker with progression from A- to A+ and with rate of amyloid PET change.

Results

Interquartile range differences in amyloid beta 42/40, percent phosphorylated tau 217 (%p-tau217), and Amyloid Probability Score 2 were associated with 1.29 (P = 0.09), 1.38 (P < 0.001), and 1.20 (P = 0.05) increases, respectively, in

SUBMITTER: Cogswell PM 

PROVIDER: S-EPMC11848042 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature