Neural deterioration and compensation in visual short-term memory among individuals with amnestic mild cognitive impairment.

ABSTRACT:

Introduction

Visual short-term memory (VSTM) is a critical indicator of Alzheimer's disease (AD), but whether its neural substrates could adapt to early disease progression and contribute to cognitive resilience in amnestic mild cognitive impairment (aMCI) has been unclear.

Methods

Fifty-five aMCI patients and 68 normal controls (NC) performed a change-detection task and underwent multimodal neuroimaging scanning.

Results

Among the atrophic brain regions in aMCI, VSTM performance correlated with the volume of the right prefrontal cortex (PFC) but not the medial temporal lobe (MTL), and this correlation was mainly present in patients with greater MTL atrophy. Furthermore, VSTM was primarily correlated with frontal structural connectivity in aMCI but was correlated with

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11848150 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature