Plasma proteomic characterization of motoric cognitive risk and mild cognitive impairment.

ABSTRACT:

Introduction

Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by mobility and cognitive dysfunction. This study conducted a proteome-wide study of MCR and compared the proteomic signatures of MCR to that of mild cognitive impairment (MCI).

Methods

Participants were classified as MCR using a memory questionnaire and 4-meter walk. We measured 4877 plasma proteins collected during late-life and midlife. Multivariable logistic regression related each protein to late-life MCR/MCI. MCR-associated proteins were replicated internally at midlife and in an external cohort.

Results

Proteome-wide analysis (n = 4076) identified 25 MCR-associated proteins. Eight of these proteins remained associated with late-life MCR when measured during midlife. Two proteins

SUBMITTER: Gomez GT 

PROVIDER: S-EPMC11848158 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature