Prescription opioid use and cognitive function in older adults with chronic pain: A population-based longitudinal cohort study.

ABSTRACT:

Introduction

Whether prescription opioid exposure, duration, and dose are associated with cognitive function remains inconclusive.

Methods

A longitudinal cohort among 3097 older adults with chronic pain and without dementia was conducted using Health and Retirement Study (HRS) linked to Medicare data from 2006 to 2020. Prescription opioid exposure, cumulative use for ≥ 90 days, and high-dose use (≥ 90 morphine milligram equivalents [MME] daily) were assessed biennially. Memory score and dementia probability were derived from HRS cognitive measures and analyzed using linear mixed-effects models.

Results

Adjusted memory decline and dementia probability were not statistically different between patients with (vs. without) opioid exposure and between patients with cumulati

SUBMITTER: Wei YJ 

PROVIDER: S-EPMC11848163 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature