Mapping reactive astrogliosis in Parkinson's brain with astroglial tracers BU99008 and Deprenyl: New insights from a multi-marker postmortem study.

ABSTRACT:

Background

Despite significant astrocytic involvement in Parkinson's disease (PD), the knowledge regarding the role of reactive astrogliosis is still at the surface level; largely due to lack of specific biomarkers to track these processes. Novel astroglial PET-tracers BU99008 and Deprenyl, hold immense potential for visualizing reactive astrogliosis in PD.  However, they have not been thoroughly investigated in PD.

Methods

We employed a multi-marker approach and performed in vitro radioligand binding and autoradiography studies with ³H-BU99008 and ³H-Deprenyl together with astrocytic immunofluorescence and morphometric analyses in the frontal cortex, temporal cortex, caudate and putamen brain regions of PD (n = 4) and control (n = 7) cases.

Results

SUBMITTER: Rocha FM 

PROVIDER: S-EPMC11848164 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature