Developing machine-learning-based amyloidogenicity predictors with Cross-Beta DB.

ABSTRACT:

Introduction

The importance of protein amyloidogenesis, associated with various diseases and functional roles, has driven the creation of computational predictors of amyloidogenicity. The accuracy of these predictors, particularly those utilizing artificial intelligence technologies, heavily depends on the quality of the data.

Methods

We built Cross-Beta DB, a database containing high-quality data on known cross-β amyloids formed under natural conditions. We used it to train and benchmark several machine-learning (ML) algorithms to predict amyloid-forming potential of proteins.

Results

We developed the Cross-Beta predictor using an Extra trees ML algorithm, which outperforms other amyloid predictors with the highest F1 score (0.852) and accuracy (0.844) compared to ex

SUBMITTER: Gonay V 

PROVIDER: S-EPMC11848165 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature