Development of Synthetic Antimicrobial Peptides Based on Genomic Analysis of Streptococcus salivarius.

ABSTRACT:

Background

In the oral environment, the production of bacteriocins or antimicrobial peptides (AMPs) plays a crucial role in maintaining ecological balance by impeding the proliferation of closely related microorganisms. This study aims to conduct in silico genome screening of Streptococcus salivarius to identify potential antimicrobial compounds existing as hypothetical peptides, with the goal of developing novel synthetic antimicrobial peptides.

Methods

Draft genomes of various oral Streptococcus salivarius strains were obtained from the NCBI database and subjected to analysis using bioinformatic tools, viz. Expert Protein-Analysis System (Expasy), UniProt Knowledgebase (UniProtKB), European Molecular Biology Open Software Suite (EMBOSS), Pepwheel, and PEP-FOLD Peptide Stru

SUBMITTER: Grover V 

PROVIDER: S-EPMC11848166 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature