Sex-dependent molecular landscape of Alzheimer's disease revealed by large-scale single-cell transcriptomics.

ABSTRACT:

Introduction

Alzheimer's disease (AD) shows significant sex differences in prevalence and clinical manifestations, but the underlying molecular mechanisms remain unclear.

Methods

This study used a large-scale, single-cell transcriptomic atlas of the human prefrontal cortex to investigate sex-dependent molecular changes in AD. Our approach combined cell type-specific and sex-specific differential gene expression analysis, pathway enrichment, gene regulatory network construction, and cell-cell communication analysis to identify sex-dependent changes.

Results

We found significant sex-specific gene expression patterns and pathway alterations in AD. Male astrocytes showed changes in cell death pathways, with RPTOR as a key regulator, while female astrocytes had alterations

SUBMITTER: Soudy M 

PROVIDER: S-EPMC11848167 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature