Tau pathway-based gene analysis on PET identifies CLU and FYN in a Korean cohort.

ABSTRACT:

Introduction

The influence of genetic variation on tau protein aggregation, a key factor in Alzheimer's disease (AD), remains not fully understood. We aimed to identify novel genes associated with brain tau deposition using pathway-based candidate gene association analysis in a Korean cohort.

Methods

We analyzed data for 146 older adults from the well-established Korean AD continuum cohort (Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease; KBASE). Fifteen candidate genes related to both tau pathways and AD were selected. Association analyses were performed using PLINK: A tool set for whole-genome association and population-based linkage analyses (PLINK) on tau deposition measured by ¹⁸F-AV-1451 positron emission tomography (PE

SUBMITTER: Yi D 

PROVIDER: S-EPMC11848168 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature