Pathological angiogenesis was associated with cerebrovascular lesion and neurodegeneration in Alzheimer's disease.

ABSTRACT:

Introduction

We investigated the specific factors driving abnormal angiogenesis in Alzheimer's disease (AD) and its role in cerebrovascular lesions and neurodegeneration.

Methods

We assessed cerebrovascular pathologies, amyloid-beta (Aβ), and tau pathologies in post mortem human brains and detected 12 angiogenic factors in cerebrospinal fluid (CSF) from the China Aging and Neurodegenerative Disease Initiative (CANDI) cohort.

Results

We observed severe blood-brain barrier damage and elevated levels of the vascular marker CD31 in human AD brains, which had a stronger correlation with tau pathology than Aβ pathology. Consistently, only CSF pTau181 showed positive associations with CSF angiogenesis factors (soluble vascular endothelial growth factor receptor 2 [sVEGFR2],

SUBMITTER: Gao F 

PROVIDER: S-EPMC11848169 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature