Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome.

ABSTRACT:

Introduction

Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.

Methods

Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic). Cortical thickness and subcortical volumes were compared between DS groups and evaluated as a staging metric using receiver operating characteristic analyses. Thickness patterns were compared to those previously reported in autosomal-dominant AD (ADAD).

Results

Decreased parietal and temporal lobe thickness differentiated amyloid positivity (area under the curve [AUC] = 0.83) and impairment (AUC = 0.81), and sli

SUBMITTER: Kennedy JT 

PROVIDER: S-EPMC11848172 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature