Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure.

ABSTRACT:

Introduction

Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear.

Methods

A total of 109 cognitively normal older adults (70+ years old) underwent amyloid beta (Aβ) and tau positron emission tomography (PET) imaging, structural magnetic resonance imaging (MRI), and cognitive testing. Cognitive aging was quantified using the cognitive age gap (CAG), subtracting chronological age from predicted cognitive age.

Results

Lower CAG (younger cognitive age) was related to slower decline in episodic memory, multi-domain cognition, and atrophy of the midcingulate cortex (MCC). Lower entorhinal cortical tau was linked to slower decline in episodic memory, multi-domain

SUBMITTER: Pezzoli S 

PROVIDER: S-EPMC11848174 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature