Compositional brain scores capture Alzheimer's disease-specific structural brain patterns along the disease continuum.

ABSTRACT:

Introduction

Traditional multivariate methods for neuroimaging studies overlook the interdependent relationship between brain features. This study addresses this gap by analyzing relative brain volumetric patterns to capture how Alzheimer's disease (AD) and genetics influence brain structure along the disease continuum.

Methods

This study analyzed data from participants across the AD continuum from the Alzheimer's and Families (ALFA) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies. Compositional data analysis (CoDA) was exploited to examine relative brain volumetric variations that (1) were linked to different AD stages compared to cognitively unimpaired amyloid-β-negative (CU A-) individuals and (2) varied by AD genetic risk.

Results

Disease stage-spec

SUBMITTER: Genius P 

PROVIDER: S-EPMC11848177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature