Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials.

ABSTRACT:

Introduction

It is unknown in which, if any, subgroups of older adults multidomain interventions are effective at reducing long-term dementia incidence.

Methods

We pooled up to 12 years of follow-up data from 5205 participants aged > 70 from the Multidomain Alzheimer Preventive Trial (MAPT) and Prevention of Dementia by Intensive Vascular Care (preDIVA) studies. The primary outcome was incident all-cause dementia. Pre-specified subgroups were defined by dementia risk factors (age, sex, education, apolipoprotein E [APOE] genotype, cognitive status, and cardiovascular risk factors).

Results

Four hundred eighty-six participants developed dementia during 37,782 person-years of follow-up. Higher incidence was associated with baseline age, APOE ε4 genotype, physical inactiv

SUBMITTER: Coley N 

PROVIDER: S-EPMC11848180 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature