Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS.

ABSTRACT:

Introduction

Early-onset Alzheimer's disease (EOAD) manifests prior to the age of 65, and affects 4%-8% of patients with Alzheimer's disease (AD). The current analyses sought to examine longitudinal cognitive trajectories of participants with early-onset dementia.

Methods

Data from 307 cognitively normal (CN) volunteer participants and those with amyloid-positive EOAD or amyloid-negative cognitive impairment (EOnonAD) were compared. Cognitive trajectories across a comprehensive cognitive battery spanning 42 months were examined using mixed-effects modeling.

Results

The EOAD group displayed worse cognition at baseline relative to EOnonAD and CN groups, and more aggressive declines in cognition over time. The largest effects were observed on measures of executive functi

SUBMITTER: Hammers DB 

PROVIDER: S-EPMC11848182 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature