Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI study.

ABSTRACT:

Introduction

Subjective cognitive decline (SCD) is linked to memory complaints and disruptions in certain brain regions identified by molecular imaging and resting-state functional magnetic resonance imaging studies. However, it remains unclear how these regions interact to contribute to both subjective and potential objective memory issues in SCD.

Methods

To address this gap, task-based imaging studies are essential. The Mnemonic Similarity Task assessed high-fidelity retrieval meanwhile MRI data measured group differences in activation and functional connectivity (FC) (calculated by generalized psychophysiological Interaction) between SCD individuals and normal controls.

Results

Worse high-fidelity retrieval in SCD was associated with hypoactivation in the hippocamp

SUBMITTER: Tang W 

PROVIDER: S-EPMC11848185 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature