Resilience to Alzheimer's disease associates with alterations in perineuronal nets.

ABSTRACT:

Introduction

Some individuals show intact cognition despite the presence of neuropathological hallmarks of Alzheimer's disease (AD). The plasticity of parvalbumin (PV)-containing interneurons might contribute to resilience. Perineuronal nets (PNNs), that is, extracellular matrix structures around neurons, modulate PV neuron function. We hypothesize that PNNs play a role in resilience to AD.

Methods

PNN amount and morphology were determined in immunolabelled sections of the frontal cortex of control, AD and resilient subjects. Expression levels of genes related to PNNs and microglia signatures were evaluated by bulk RNA sequencing.

Results

The expression of the PNN-component aggrecan around PV neurons is decreased in resilient and AD subjects, whereas PNN-sugar chains

SUBMITTER: de Vries LE 

PROVIDER: S-EPMC11848190 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature