Plasma p-tau₂₁₇ and neurofilament/p-tau₂₁₇ ratio in differentiating Alzheimer's disease from syndromes associated with frontotemporal lobar degeneration.

ABSTRACT:

Introduction

Plasma-based biomarkers have shown promise for clinical implementation, but their accuracy in differentiating Alzheimer's disease (AD) from syndromes associated with frontotemporal lobar degeneration (FTLD) has yet to be fully investigated. This study assessed the potential of plasma biomarkers for differential diagnosis.

Methods

This cohort study included 374 participants (96 AD, 278 FTLD). Plasma phosphorylated tau (p-tau)₂₁₇, neurofilament light chain (NfL), brain-derived tau, glial fibrillary acidic protein, and the amyloid beta_1-42/_1-40 ratio were measured. Receiver operating characteristic curve analyses assessed diagnostic accuracy, and a three-range threshold approach was used to stratify patients based on the most accura

SUBMITTER: Benussi A 

PROVIDER: S-EPMC11848195 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature