Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution.

ABSTRACT:

Introduction

Using a single-nucleus transcriptome derived from the dorsolateral prefrontal cortex of 424 Religious Orders Study and the Rush Memory and Aging Project (ROS/MAP) participants, we investigated the cell type-specific effect of ten vascular endothelial growth factor (VEGF) genes on Alzheimer's disease (AD) endophenotypes.

Methods

Negative binomial mixed models were used for differential gene expression and association analysis with AD endophenotypes. VEGF-associated intercellular communication was also profiled.

Results

Higher microglia FLT1, endothelial FLT4, and oligodendrocyte VEGFB are associated with greater amyloid beta (Aβ) load, whereas higher VEGFB expression in inhibitory neurons is associated with lower Aβ load. Higher astrocyte NRP1 is associate

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11848196 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature