Neuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.

ABSTRACT:

Background

We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria.

Methods

Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.

Results

We included 26 studies and 2823 participants. Across all domains, the MCI-LB group performed worse than controls and better than DLB. Compared to MCI-AD, the MCI-LB group performed worse in attention/processing speed (g = -0.24, 95% confidence interval [CI]: -0.35, -0.12), a

SUBMITTER: Wyman-Chick KA 

PROVIDER: S-EPMC11848198 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature