Multimodal imaging of murine cerebrovascular dynamics induced by transcranial pulse stimulation.

ABSTRACT:

Introduction

Transcranial pulse stimulation (TPS) is increasingly being investigated as a promising potential treatment for Alzheimer's disease (AD). Although the safety and preliminary clinical efficacy of TPS short pulses have been supported by neuropsychological scores in treated AD patients, its fundamental mechanisms are uncharted.

Methods

Herein, we used a multi-modal preclinical imaging platform combining real-time volumetric optoacoustic tomography, contrast-enhanced magnetic resonance imaging, and ex vivo immunofluorescence to comprehensively analyze structural and hemodynamic effects induced by TPS. Cohorts of healthy and AD transgenic mice were imaged during and after TPS exposure at various per-pulse energy levels.

Results

TPS enhanced the microvascular ne

SUBMITTER: Karakatsani ME 

PROVIDER: S-EPMC11848200 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature