Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease.

ABSTRACT:

Introduction

We investigated whether the cerebellum develops neuropathology that correlates with well-accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.

Methods

We studied cerebellar cytoarchitecture in a cohort (N = 30) of brain donors. In a larger cohort (N = 605), we queried whether the weight of the contents of the posterior fossa (PF), which contains primarily cerebellum, correlated with dementia status.

Results

Although there was no granular layer (GL) cell loss, GL area was lower in AD cases, particularly in the lateral cerebellum. Lower numbers of mossy fiber synaptic terminals in the cerebellar GL of AD cases correlated with Braak stages IV-VI. PF content weight correlated with dementia independently of age, neuropathology, and

SUBMITTER: Samstag CL 

PROVIDER: S-EPMC11848203 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature