Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study.

ABSTRACT:

Background

Major depressive disorder (MDD) is a leading cause of disability, with a twofold increase in prevalence in women compared to men. Over the last few years, identifying molecular biomarkers of MDD has proven challenging, reflecting interactions among multiple environmental and genetic factors. Recently, epigenetic processes have been proposed as mediators of such interactions, with the potential for biomarker development.

Methods

We characterised gene expression and two mechanisms of epigenomic regulation, DNA methylation (DNAm) and microRNAs (miRNAs), in blood samples from a cohort of individuals with MDD and healthy controls (n = 169). Case-control comparisons were conducted for each omic layer. We also defined gene coexpression networks, followed by step-by-step

SUBMITTER: Mokhtari A 

PROVIDER: S-EPMC11848217 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature