Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.

ABSTRACT:

Background

Shigella sonnei has caused sexually transmitted enteric infections in men who have sex with men (MSM) in Vancouver. We recently observed a high rate of multidrug-resistant (MDR) S. sonnei bacteremia among persons experiencing homelessness (PEH). We aimed to describe the wider epidemiology, clinical outcomes, and genomics of S. sonnei infections over time.

Methods

A retrospective review of 163 patients with S. sonnei infections was undertaken from 2015 to 2022. We collected demographic, clinical, and microbiological data over 2 time periods: historical (2015-2020) and recent (2021-2022). Severe shigellosis definition included hospitalization, bacteremia, or death. Whole-genome sequencing was performed to identify genotype, infer relatedness, and predict antimicrobi

SUBMITTER: Stefanovic A 

PROVIDER: S-EPMC11848260 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature