Community-acquired Pneumonia in People With HIV During the Current Era of Effective Antiretroviral Therapy: A Multicenter Retrospective Cohort Study.

ABSTRACT:

Background

It is unclear if human immunodeficiency virus (HIV) affects the prognosis for community-acquired pneumonia (CAP) in the current era of effective antiretroviral therapy. In this multicenter retrospective cohort study of patients admitted for CAP, we compared the in-hospital mortality rate between people with HIV (PWH) and those without.

Methods

The study included consecutive patients admitted with a diagnosis of CAP across 31 hospitals in Ontario, Canada, from 2015 to 2022. HIV infection was based on discharge diagnoses and antiretroviral prescription. The primary outcome was in-hospital mortality. Competing risk models were used to describe time to death in hospital or discharge. Potential confounders were balanced using overlap weighting of propensity scores.

SUBMITTER: Bai AD 

PROVIDER: S-EPMC11848276 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature