Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex.

ABSTRACT: How early sensory experience during "critical periods" of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previously reported that the functional and molecular profiles of layer 2/3 (L2/3) cell types in the primary visual cortex (V1) are vision-dependent [S. Cheng et al., Cell 185, 311-327.e24 (2022)]. Here, we characterize the spatial organization of L2/3 cell types with and without visual experience. Spatial transcriptomic profiling based on 500 genes recapitulates the zonation of L2/3 cell types along the pial-ventricular axis in V1. By applying multitasking theory, we suggest that the spatial zonation of L2/3 cell types is linked to the continuous nature of their gene expression pr

SUBMITTER: Xie F 

PROVIDER: S-EPMC11848306 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature