Educational attainment, Aβ, tau, and structural brain reserve in Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) patients with higher educational attainment (EA) often exhibit better cognitive function. However, the relationship among EA status, AD pathology, structural brain reserve, and cognitive decline requires further investigation.

Methods

We compared cognitive performance across different amyloid beta (Aβ) positron emission tomography (A ±) statuses and EA levels (High EA/Low EA). We examined the effects of Aβ plaques, tau tangles, and gray matter volume (GMV) on the relationship between EA and domain-specific cognitive decline.

Results

A+/High-EA individuals exhibited slower cognitive decline in global cognition and language domains than A+/Low-EA individuals. This cognitive benefit was independently and synergistically explained by

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11848334 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature