Influence of medical conditions on the diagnostic accuracy of plasma p-tau217 and p-tau217/Aβ42.

ABSTRACT:

Introduction

Blood-based biomarkers (BBMs) can enable early detection of brain amyloid beta (Aβ) pathology in cognitively unimpaired individuals. However, the extent to which common medical conditions affect biomarker performance remains unclear.

Methods

Participants (n = 348) included individuals without cognitive impairment. We studied how brain Aβ associated with BBMs (Aβ42/40, phosphorylated tau [p-tau] 181 and 217, p-tau217/Aβ42, glial fibrillary acidic protein [GFAP], and neurofilament light [NfL]) and optimal BBM thresholds for predicting brain Aβ positivity and whether they are obscured by the presence of common medical conditions.

Results

Plasma Aβ42/40, p-tau181, p-tau217, and GFAP, but not NfL, were significantly associated with brain Aβ. P-tau217/Aβ42 show

SUBMITTER: Olvera-Rojas M 

PROVIDER: S-EPMC11848339 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature