Longitudinal synaptic loss versus tau Braak staging in amnestic mild cognitive impairment.

ABSTRACT:

Introduction

The longitudinal progression of synaptic loss in Alzheimer's disease (AD) and how it is affected by tau pathology remains poorly understood.

Methods

Thirty patients with amnestic mild cognitive impairment (aMCI) and 26 healthy controls underwent cognitive evaluations and tau, synaptic vesicle protein 2A (SV2A), and amyloid positron emission tomography. Twenty-one aMCI underwent 2-year follow-up (FU) investigations.

Results

Tau levels in aMCI increased longitudinally in Braak regions III through VI but not in Braak regions I and II. SV2A decreased longitudinally in all Braak regions in aMCI. Baseline tau was negatively associated with longitudinal SV2A loss in early Braak regions and with SV2A at FU across regions. Baseline tau and longitudinal change in S

SUBMITTER: Vanderlinden G 

PROVIDER: S-EPMC11848342 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature