Retinal vasculometry associations with cognition status in UK Biobank.

ABSTRACT:

Introduction

Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale.

Methods

Artificial intelligence-enabled RV measures from 66,350 UK Biobank study participants were related to combined cognition scores. Differences in RV were examined per standard deviation (SD) increase in cognitive score, using multilevel linear regression, adjusted for age, sex, measurement center, ethnicity, and within-person RV clustering.

Results

One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased a

SUBMITTER: Shakespeare R 

PROVIDER: S-EPMC11848343 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature