Locus coeruleus tau is linked to successive cortical tau accumulation.

ABSTRACT:

Introduction

We investigated the hypothesis that tau burden in the locus coeruleus (LC) correlates with tau accumulation in cortical regions according to the Braak stages and examined whether the relationships differed according to cortical amyloid beta (Aβ) deposition.

Methods

One hundred and seventy well-characterized participants from an ongoing cohort were included. High-resolution T1, tau positron emission tomography (PET), and amyloid PET were obtained.

Results

LC tau burden was significantly linked to global tau in neocortical regions, as was tau in both early Braak stage (stage I/II) and later Braak stage areas. This relationship was significant only in Aβ-positive individuals. While LC tau did not directly impact memory, it was indirectly associated with dela

SUBMITTER: Yi D 

PROVIDER: S-EPMC11848382 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature